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Anorectal Pathology with Molecular Testing2022-10-18T15:56:48+00:00

Laboratory of Choice

Children are not things to be molded but are people to be unfolded.

Science-first leaders whose compassion for healthcare providers and patients is incomparable.

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Anorectal Pathology with Molecular Testing


  • Anal Biopsies- performed on histologic sampling for anal lesions and condyloma
  • In Situ Hybridization (ISH) HPV subtyping & Immunohistochemistry (IHC) may be performed on tissue histologic samples


Performed from ThinPrep® sample

  • Anal Pap Smear- performed for cytologic screening for abnormalities
  • Molecular HPV testing available with genotyping 16, 18/45
  • Cytogenetic FISH testing

mRNA and Cervical Disease

genesis anorectal cytology chart


TERC FISH- A cytogenetic FISH test for identification of the amplification of the Telomerase RNA gene (TERC). The presence of this gene is likely to be associated with high grade intraepithelial lesions, most commonly linked to the Human papillomavirus, or HPV. By identifying the chromosomal instability or amplification of the gene, we are able to identify patients with this abnormality for better patient follow-up and care.

NORMAL: TERC Negative Cell

Molecular Microbiology

Performed from Aptima® Swab

  • Anogenital
  • Chlamydia trachomatis
  • Neisseria gonorrhoeae
  • Herpes Simplex Virus 1
  • Herpes Simplex Virus 2

The CDC recommends chlamydia screening in the following sexually active populations:

  • Women younger than 25 years old
  • Women 25 years old and older with risk factors such as new or multiple sex partners or a sex partner with an STI
  • All pregnant women
  • Annual screening for gay, bisexual and other men who have sex with men (MSM)

Aptima® Multitest Swab

  • Clinician-collected sample: vaginal, throat, and rectal swab
  • Patient-collected sample: vaginal swab

Now Available with Throat and Rectal Sample

Hologic Aptima Swab

Aptima® Combo 2 Assay

genesis Aptima Combo 2 Assay Chart 2

Limitations of Culture Testing Could Impact Patients

genesis Limitations of Culture Testing Could Impact Patients

The Aptima® HSV 1 & 2 Assay: Proven Performance in Sensitivity and Specificity

genesis The Aptima HSV 1 & 2 Assay Proven Performance in Sensitivity and Specificity

Keep up-to-date with Genesis Labs.


  • CDC. Sexually Transmitted Diseases. STDs & Infertility. https://www.cdc.gov/std/Infertility/default.htm. Last reviewed October 30, 2013. Accessed May 8, 2019.
  • CDC. Recommendations for the Laboratory-Based Detection of Chlamydia tachomatis and Neisseria gonorrhoeae — 2014. MMWR Recom Rep. 2014;63(RR02):1-19.
  • Cernesky M, et al. High analytical sensitivity and low rates of inhibition may contribute to detection of Chlamydia trachoma’s in significantly more women by the APTIMA Combo 2 assay. J Clin Microbiol. 2006;44(2): 4:00-405. dol:10.1128/JCM.44.2.400-405.2006
  • Aptima Combo 2 Assay (Panther system) [package insert]. 502466-IFU-PI. San Diego, CA; Hologic, Inc. 2018
  • Chemesky M, et al. Head-to-head vaginal swabs. J Clin Microbien. 2014;52(7):2305-2310. dol:10.1125/JCM.03552-13.
  • Hologic.com, HSV1 & 2 Physician Brochure, 2019.
  • Hologic.com, Aptima HPV Brochure, 2018.
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