C. difficile carrier state is common (about 10% of adults and a much higher incidence in infants and children). Detection of toxigenic C. difficile on PCR does not automatically imply that C. difficile infection (CDI) is causing a particular case of diarrhea, as many studies show that other pathogens may be responsible for acute diarrhea in many C. difficile carriers. To provide more information in such a scenario, our lab reflexes all samples detected to have C. difficile on FilmArray® testing to a further C. difficile Toxin A/B rapid enzyme immunoassay (EIA) test to help differentiate the presence of C. difficile infection (CDI) from a carrier state. Most clinical and laboratory experts agree that testing for stool Toxin A/B should be a part of making a diagnosis of CDI. However, it seems to be rarely performed in most commercial laboratories in such situations¹.