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Cytology and FISH


Diagnostic cytology of the gastrointestinal tract is composed of the esophagus, stomach, and small and large intestine. Cytologic samples may be submitted fixed in 95% ethanol or a rinsing medium such as Cytolyt.

Smears and/or liquid-based preparations are made and stained for screening and diagnostic purposes performed by certified cytotechnologists and pathologists.

Cytology and FISH - Gastroenterology

Example of normal squamous cells within esophageal brushing sample.

Cytology and FISH 2 - Gastroenterology

Example of Positive Gastric brushing with pap stain.

Barrett’s Esophagus FISH

Fluorescent In-Situ Hybridization (FISH) is performed on samples of Barrett’s epithelium of the esophagus, determining the risk of developing dysplasia and malignancy in patients with known Barrett’s Esophagus.

Genesis Labs Barrett's Esophagus FISH

This Assay is tested using cytology brushings from known Barrett’s esophagus (BE) patients and/or suspected BE nodules to help determine the risk of developing dysplasia and adenocarcinoma. Cytology specimens collected via endoscopic brushing result in more comprehensive and wide area tissue sampling than biopsies alone. FISH testing is performed on the cytology sample as an adjunct to the four quadrant biopsies. Studies have shown progression to High-Grade Dysplasia & Esophageal Adenocarcinoma in spite of no dysplasia being seen on traditional biopsies within 33 months of significant genetic abnormalities and if polysomy is seen on the FISH testing1. Barrett’s FISH uses probes that help identify genes, including MYC, p16, HER2, and ZNF217.


Positive (Polysomy)


Negative (Normal)


Positive (Homozygous 9p21 deletion)


Positive (Single gain)


The Human Epidermal growth factor receptor 2, known as HER2, is frequently recognized as being overexpressed in gastroesophageal cancers. With the molecular abnormalities identified utilizing our HER2 FISH panel, we are able to provide clinicians with additional options for treatment for advanced gastric cancer.

Genesis Labs HER2 FISH

Cytology and FISH

Cytology and FISH


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